Polysarcosine (pSar), a peptide like polymer, comes from sarcosine and offers great water solubility, protein resistance, and low toxicity. It works well in lipid nanoparticles (LNPs) for mRNA delivery. As a biocompatible alternative to PEG, pSar suits drug delivery and surface coating applications perfectly.
Polysarcosine
Polysarcosine (pSar) is a peptide-like polymer made from the endogenous amino acid sarcosine (N-methylated glycine). It offers strong stealth properties and a range of useful features.
Key Features:
- Structure: pSar, built from sarcosine units, provides a peptide-like structure that enhances biocompatibility.
- Stealth Properties: It combines excellent water solubility, protein resistance, low cytotoxicity, and non-immunogenicity. Unlike PEG, it is based on natural, endogenous materials.
- Applications:
- Lipid Nanoparticles (LNPs): pSar works well in generating lipids for forming LNPs, which play a key role in delivering therapeutic mRNA.
- Drug Delivery: Its stealth properties improve circulation time and boost drug stability.
- Bioconjugation: It effectively attaches to nanoparticles, proteins, and other biomolecules.
- Surface Coatings: pSar reduces protein adsorption and non-specific binding, making it useful for medical devices.
- PEG Alternative: As an alternative to PEG, pSar offers the same benefits, like non-immunogenicity and protein resistance, while being more biocompatible.