Advanced Glucuronide Linkage Solutions for Cutting-Edge Research
Elevate your research and development with our premium Glucuronide Linker. Designed for precision and efficiency, our Glucuronide Linker offers an innovative solution for chemical and biological applications, providing enhanced functionality and versatility.
β-Glucuronide Linkers is an enzyme-labile linker used in the development of antibody-drug conjugates. The β-Glucuronide and cytotoxic drug conjugate complex undergoes cleavage by β-glucuronidase and releases the cytotoxic drug. β-glucuronidase is an enzyme present in lysosomes and over expressed in some tumors.
Unlike dipeptide-based ADCs that are prone to aggregation, β-glucuronide linkers have hydrophilic properties that may potentially reduce aggregation of the hydrophobic drugs and promote the solubility of intact antibody-drug conjugates.
Why Choose Our Glucuronide Linker?
1. Exceptional Reactivity and Stability
Our Glucuronide Linker is engineered for optimal reactivity and stability, ensuring reliable and efficient conjugation. Its robust design supports consistent results across a variety of applications.
2. Enhanced Drug Delivery Efficiency
Our Glucuronide Linker is designed to improve the efficacy of drug delivery systems. By enabling precise release and activation of therapeutic agents, it enhances the performance and targeting of drug products.
3. Versatile Applications
- Drug Development: Facilitate the design of prodrugs and improve bioavailability with advanced glucuronide conjugation.
- Biochemical Research: Enhance studies in metabolism and pharmacokinetics by using glucuronide linkages to track and analyze compounds.
- Diagnostic and Therapeutic Applications: Develop novel diagnostic assays and targeted therapies with improved specificity and performance.
4. High Purity and Quality
Manufactured to the highest standards, our Glucuronide Linker ensures superior purity and quality. Each batch undergoes rigorous testing to meet your exacting research requirements.
5. Ease of Use
Our linker integrates seamlessly into your existing protocols, making it simple to incorporate into various chemical and biological systems. Benefit from straightforward handling and minimal preparation.
Ref:
Jeffrey SC, De Brabander J, Miyamoto J, Senter PD. Expanded Utility of the β-Glucuronide Linker: ADCs That Deliver Phenolic Cytotoxic Agents. ACS Med Chem Lett. 2010 Jun 14;1(6):277-80.
Su Z, Xiao D, Xie F, Liu L, Wang Y, Fan S, Zhou X, Li S. Antibody-drug conjugates: Recent advances in linker chemistry. Acta Pharm Sin B. 2021 Dec;11(12):3889-3907.
