Amine-PEG (PEG Amine) linkers feature an amino group on one end of the PEG spacer, which reacts easily with acids, acyl chlorides, NHS esters, or PFP esters. These linkers are widely used in labeling, bioconjugation, chemical modification, and surface applications. The PEG spacer in the middle boosts aqueous solubility, making the linkers more effective in biological environments.
AxisPharm’s Amine-PEG products offer defined PEG lengths for precise tuning of the distance between ADC mAbs and payloads. The high-purity PEG-NH2 reagents come in various linker lengths, with custom options available.
Amino PEG
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Amine-PEG (PEG Amine) Overview
Amine-PEG (PEG Amine) offers a flexible reagent with a PEG chain and a terminal amine group. The amine easily reacts with carboxyls, NHS esters, and other reactive groups, while the PEG chain boosts solubility and biocompatibility. It works well in bioconjugation, drug delivery, and surface modification.
Key Features:
- Amine Group: Quickly reacts with carboxyls and other groups for efficient linking.
- PEG Chain: Improves solubility, reduces immune responses, and increases stability.
- Biocompatibility: PEGylation minimizes protein adsorption and enhances tissue compatibility.
Applications:
- Bioconjugation: Links proteins, peptides, and molecules through amine-coupling.
- Drug Delivery: Increases solubility and circulation of therapeutic agents.
- Surface Modification: Coats surfaces, creating hydrophilic, biocompatible layers on devices or particles.
Advantages:
- High Reactivity: The amine ensures strong, stable connections.
- Enhanced Solubility: PEG backbone boosts water solubility and prevents aggregation.
- Versatile Applications: Ideal for drug development, bioconjugation, and material science.