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Aldehyde PEG Linkers are advanced PEG derivatives featuring an aldehyde group, designed for reversible conjugation in Antibody-Drug Conjugates (ADCs). They provide precise control over the attachment and release of therapeutic drugs, enhancing targeted therapies. The aldehyde group enables stable yet reversible linkages, while the PEG spacer improves solubility and reduces aggregation. These linkers are pivotal in ADC development, controlled release systems, and targeted therapies, offering flexibility and high specificity.

Cat# Name Structure M.W. Purity Pricing
Ald-benzoylamide-PEG-CH2 acid
AP10080Ald-benzoylamide-PEG2-CH2 acid295.29≥95% Pricing
AP10081Ald-benzoylamide-PEG3-CH2 acid339.34≥95% Pricing
AP10079Ald-benzoylamide-PEG4-CH2 acid383.39≥95% Pricing
ald-benzoylamide-PEG-CH2 NHS ester
AP10068Ald-benzoylamide-PEG2-CH2 NHS ester392.36≥95% Pricing
AP10066Ald-benzoylamide-PEG3-CH2 NHS ester436.41≥95% Pricing
AP10064Ald-benzoylamide-PEG4-CH2 NHS ester480.47≥95% Pricing
Ald-benzyl-PEG-CH2 tBu-ester
AP10075Ald-benzyl-PEG4-CH2 tBu-ester368.42≥95% Pricing
AP10077Ald-benzyl-PEG5-CH2 tBu-ester412.47≥95% Pricing
Ald-benzyl-PEG-propargyl
AP10112Ald-benzyl-PEG4-propargyl292.33≥95% Pricing
AP10111Ald-benzyl-amide-PEG3-propargyl319.35≥95% Pricing
AP10113Ald-benzyl-PEG5-propargyl336.38≥95% Pricing
AP10110Ald-benzyl-amide-PEG4-propargyl363.4≥95% Pricing
Ald-CH2-PEG-Azide
AP10065Ald-CH2-PEG2-Azide173.17≥95% Pricing
AP12260Ald-CH2-PEG3-azide217.23≥95% Pricing
AP12261Ald-CH2-PEG5-azide305.33≥95% Pricing
AP12262Ald-CH2-PEG8-azide437.49≥95% Pricing
Ald-CH2-PEG-CH2CO2tBu
AP10036Ald-CH2-PEG2-CH2CO2 tBu ester218.25≥98% Pricing
AP10035Ald-CH2-PEG4-CH2CO2 tBu ester306.35≥98% Pricing
Ald-CH2-PEG-NHBoc
AP10071Ald-CH2-PEG2-NHBoc247.29≥95% Pricing
AP10070Ald-CH2-PEG3-NHBoc291.34≥95% Pricing
AP10072Ald-CH2-PEG4-NHBoc335.39≥95% Pricing
Ald-CH2-PEG-propargyl
AP10043Ald-CH2-PEG3-propargyl186.21≥95% Pricing
AP10044Ald-CH2-PEG4-propargyl230.26≥95% Pricing
Ald-CH2-PEG-t-butyl ester
AP12703Ald-CH2-PEG2-t-butyl ester232.27≥95% Pricing
AP12254Ald-CH2-PEG4-t-butyl ester320.38≥95% Pricing
AP12255Ald-CH2-PEG5-t-butyl ester364.44≥95% Pricing
AP12256Ald-CH2-PEG10-t-butyl ester584.7≥95% Pricing
Ald-PEG-acid
AP12239Ald-Ph-PEG2-acid309.32≥95% Pricing
AP12240Ald-Ph-PEG4-acid397.42≥95% Pricing
AP12241Ald-Ph-PEG6-acid485.53≥95% Pricing
AP12242Ald-Ph-PEG24-acid1278.48≥95% Pricing
Ald-PEG-amine
AP12257Ald-Ph-PEG2-amine TFA salt280.32≥95% Pricing
AP12258Ald-Ph-PEG3-amine TFA salt324.38≥95% Pricing
Ald-PEG-Azide
AP152554-Azidobenzaldehyde147.13≥95% Pricing
AP10073Ald-PEG3-azide231.25≥95% Pricing
AP12259Ald-PEG4-azide275.31≥95% Pricing
AP10074Benzaldehyde-PEG4-azide323.34≥95% Pricing
Ald-PEG-NH-Boc
AP12704Ald-PEG2-NHBoc261.31≥95% Pricing
AP10067Ald-PEG3-NHBoc305.37≥95% Pricing
AP10069Ald-PEG4-NHBoc349.42≥95% Pricing
AP12264Ald-Ph-PEG2-NH-Boc380.44≥95% Pricing
AP12265Ald-Ph-PEG3-NH-Boc424.49≥95% Pricing
Ald-PEG-NHS ester
AP12243Ald-Ph-PEG2-NHS406.39≥95% Pricing
AP12244Ald-Ph-PEG4-NHS ester494.5≥95% Pricing
AP12245Ald-Ph-PEG24-NHS ester1375.56≥95% Pricing
Ald-PEG-t-butyl ester
AP12248Ald-PEG1-t-butyl ester202.25≥95% Pricing
AP12249Ald-Ph-PEG2-t-butyl ester365.43≥95% Pricing
AP12253Ald-Ph-PEG5-t-butyl ester426.51≥95% Pricing
AP12250Ald-Ph-PEG4-t-butyl ester453.53≥95% Pricing
AP12251Ald-Ph-PEG6-t-butyl ester541.64≥95% Pricing
Ald-PEG-TFP ester
AP15172Ald-PEG4-TFP545.48≥95% Pricing
AP12246Ald-Ph-PEG12-TFP ester897.91≥95% Pricing
AP12247Ald-Ph-PEG24-TFP ester1426.54≥95% Pricing
Ald-PEG-Thiol
AP15252Ald-PEG23-Thiol1293.56≥95% Pricing
Ald-Ph-PEG-Azide
AP12263Ald-Ph-PEG3-azide350.38≥95% Pricing
AP13875Ald-Ph-PEG5-azide438.50≥95% Pricing
Ald-Ph-PEG-O-NH-Boc
AP12266Ald-Ph-PEG3-O-NH-Boc440.49≥95% Pricing
Ald-Ph-PEG-PFP
AP14149Ald-Ph-PEG4-PFP563.50≥95% Pricing
BCN-PEG-ald
AP13063exo-BCN-ald206.29≥95% Pricing
Biotin aldehyde PEG
AP10076Biotin-PEG2-CH2-aldehyde373.47≥95% Pricing
AP10078Biotin-PEG2-aldehyde387.50≥95% Pricing
DSPE-PEG-Ald
AP13637DSPE-PEG-Ald, MW 1K1000≥95% Pricing
AP13665DSPE-PEG-Ald, MW 2K2000≥95% Pricing
AP13680DSPE-PEG-Ald, MW 3.4K3400≥95% Pricing
AP13690DSPE-PEG-Ald, MW 5K5000≥95% Pricing
M-PEG-aldehyde
AP11367m-PEG3-aldehyde176.21≥95% Pricing
AP11368m-PEG4-aldehyde220.27≥95% Pricing
AP11369m-PEG7-aldehyde352.42≥95% Pricing
AP11370m-PEG8-aldehyde396.48≥95% Pricing
M-PEG-benzaldehyde
AP12238m-PEG4-benzaldehyde268.31≥95% Pricing
M-PEG-CH2-aldehyde
AP11371m-PEG4-CH2-aldehyde250.29≥95% Pricing
Phthalamidoxy-PEG-CH2-ald
AP10115Phthalamidoxy-PEG1-CH2-ald249.22≥95% Pricing
AP10114Phthalamidoxy-PEG2-CH2-ald293.27≥95% Pricing
TCO-PEG-ald
AP13064TCO-ald182.26≥95% Pricing
AP10103TCO-PEG3-CH2-ald343.42≥95% Pricing
AP10143Ald-benzyl-amine-PEG2-TCO432.52≥95% Pricing

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    Aldehyde PEG Linkers: Advanced Tools for Reversible Conjugation in ADCs Overview: Aldehyde PEG Linkers are specialized polyethylene glycol (PEG) derivatives featuring an aldehyde functional group. These innovative linkers are designed for creating reversible conjugations, particularly useful in the development of Antibody-Drug Conjugates (ADCs). They offer precise control over the attachment and release of biomolecules, enhancing the efficacy and specificity of targeted therapies.   Key Features:
    • Aldehyde Functional Group: Enables stable yet reversible linkages with hydrazide, aminooxy, and other reactive groups, facilitating flexible bioconjugation strategies.
    • PEG Spacer: Improves solubility and biocompatibility, reducing nonspecific interactions and aggregation in aqueous environments.
    Applications:
    • Reversible Conjugation: Ideal for creating dynamic linkages in ADCs, allowing for the controlled attachment and detachment of therapeutic drugs from antibodies.
    • ADC Development: Utilized in the conjugation of antibodies with cytotoxic drugs, such as doxorubicin, through hydrazone bond formation. The hydrazone linkeges are acid-labile and break down when an ADC is transported to acidic endosomes and lysosomes, which have a pH of 5.0–6.0 and 4.8, respectively. This approach ensures targeted delivery and controlled release of the drug, optimizing therapeutic outcomes.
    • Controlled Release Systems: Supports the development of drug delivery systems with precise release mechanisms in response to specific conditions.
    Benefits:
    • High Reactivity and Flexibility: The aldehyde group facilitates efficient and reversible conjugation, offering versatility in experimental designs and applications.
    • Enhanced Solubility and Stability: The PEG spacer improves solubility and reduces aggregation, ensuring effective performance in various settings.
    • Targeted Therapy: Provides the ability to create ADCs with high specificity, reducing off-target effects and enhancing treatment effectiveness.
    Ref: Fu, Z., Li, S., Han, S. et al. Antibody drug conjugate: the “biological missile” for targeted cancer therapy. Sig Transduct Target Ther 7, 93 (2022). https://doi.org/10.1038/s41392-022-00947-7 AxisPharm provides GMP grade PEG aldehyde derivatives. Aldehyde-containing PEGylated linkers with molecular weights, branches and functional groups not listed in our online catalog are available through custom synthesis.