PEG (polyethylene glycol) linkers are versatile tools in biotechnology that connect biomolecules, enhancing solubility, stability, and reducing immunogenicity. They are widely used in drug delivery, bioconjugation, and diagnostic assays. PEG linkers come in various lengths and functional groups, providing flexibility in modifying proteins, antibodies, and oligonucleotides. Their hydrophilic nature minimizes non-specific interactions, making them ideal for applications in targeted drug delivery, PEGylation of therapeutic molecules, and linking small molecules in diagnostic tests.
Different Types of Polyethylene Glycol PEG Linkers in Stock
PEG Applications
Top 10 selling High purity Polyethylene Glycol PEG Linkers
The quality, purity and homogeneity of the PEG linker can affect the success of the conjugation reaction and the stability of the final product. Buy high-quality Polyethylene Glycol PEG linkers from AxisPharm at competitive prices.
Polyethylene Glycol PEG Linkers Uses and Applications
1. Polyethylene Glycol PEG Linkers in Antibody Drug Conjugation Antibody-drug conjugates (ADCs) targeting antibody delivers a covalently attached payload to a cell type of interest, wherein the molecule is internalized and lysosomally processed and the payload is released. Pegylation of therapeutics will bring more improvements compared with regular non-pegylated ones, such as increased water solubility, improved stability, controlled release, extended drug half-life, and an enhanced PK/ PD (pharmacokinetic/pharmacodynamic) profile. PEGylation of therapeutic proteins occurs mainly in the N-terminal group, carbohydrates, sulfhydryl, and the amino acids Thr, Cys, Asp, Glu Lys, His, Arg, Tyr, and Ser. In the course of the PEGylation of small molecule drugs, a multi-arm polyethylene glycol will bond multiple drug molecules, ensuring a high drug load and an enhanced drug release. 2. Polyethylene Glycol PEG Linkers in PEGylation PEGylation of a molecule is the process by which PEG is either non-covalently or covalently attached to a potential protein, peptide, or antibody of interest to produce alterations in the physiochemical properties of the macromolecule in areas like conformation, electrostatic binding and hydrophobicity. The key advantages of attaching PEG to a biomacromolecule are to pass along PEG’s : 1) High solubility in aqueous and organic solutions 2) Its hydrophilic character 3) Its non-immunogenic properties 3. Polyethylene Glycol PEG Linkers in Click Chemistry Click chemistry features a fast, versatile, regiospecific, and a high-yield reaction. It includes azides/ terminal alkynes, azide/DBCO, azide/BCN, TCO/tetrazine, etc. It is also combined with PEG linker and has found applications in a wide variety of research areas, including materials sciences, polymer chemistry, and pharmaceutical sciences. Recently, click chemistry has become a valuable molecular imaging and drug delivery for diagnostic and therapeutic tools in the biomedical field. Click chemistry can also be used to develop molecular tools, such as DNA nanocatalysts, chemical synthesis of genomic DNA, assisted CRISPR-Cas gene editing, ADC and PROTAC synthesis, etc. 4. Polyethylene Glycol PEG Linkers in Dye Labeling Fluorescent dyes such as cyanine, fluorescein, rhodamine, etc, can be pegylated. Compared to conventional fluorescent molecules, the pegylated dyes offer improved hydrophilicity, solvent solubility, superior brightness, no self-quenching, high photostability, and less no specific binding. 5. Polyethylene Glycol PEG Linkers in Drug Delivery Emerging PEG-based drug delivery systems are the pharmaceutical industry's gold standard for treating diseases such as cancer, hemophilia, pain or diabetes. With the development of drugs from small molecules to peptides and proteins, to nucleic acid drugs, and finally to living cell therapy, new progress has been made in drug delivery technology. The challenges of various therapies can be well resolved through drug modification and microenvironment regulation. The PEG drug delivery system can be used in PEG-drug conjugation, hydrogel, nanoparticle, etc, and have the features below. Maintaining the spatial configuration and biological activity of drug molecules Promoting the targeting of drug molecules to lesion tissues or target cells Enhancing the efficiency of drug molecules across all levels of biological barriers Improving the efficiency of intracellular drug delivery and releaseAxisPharm - A Leading Polyethylene Glycol PEG Supplier
AxisPharm is a San Diego based leading PEG linker manufacturer with more than 5,000 high-purity polyethylene glycol linkers in stock. The wide selection of lengths and functionalities will empower the PEGylation, bioconjugation, crosslinking, ADC drug development and biolabeling for pharmaceutical and biotech R&D.PEG Linkers: Essential Tools for Bioconjugation and Drug Delivery
PEG (Polyethylene Glycol) linkers are key components in bioconjugation and drug delivery, enhancing the stability, solubility, and functionality of biomolecules. They connect molecular entities efficiently and are widely used in biotechnology for targeted therapies, protein engineering, diagnostic assays, and chemical synthesis.
Types of PEG Linkers:
- Linear PEG Linkers: Used in drug delivery, e.g., Pegasys®.
- Branched PEG Linkers: For multifunctional conjugates, e.g., Adcetris®.
- Cleavable PEG Linkers: Enable controlled drug release, e.g., Kadcyla®.
- Biotin-PEG Linkers: Widely used in detection assays.
- Functionalized PEG Linkers: For specific bioconjugation needs.
- Drug Delivery: Enhance stability and controlled release.
- Bioconjugation: Improve protein stability and extend drug half-life.
- Diagnostic Assays: Aid in fluorescent labeling and affinity purification.
- Chemical Synthesis: Create cross-linked materials and advanced polymers.